Can new drugs reduce TBI severity?


Clazosentan, in an animal trial, has been shown to be effective in increasing the blood flow to the hippocampus following TBI. The positive results of the animal study will hopefully move the study forward to human application. We know that intervention immediately following TBI can reduce injury severity and researchers continue to look for drugs which can intervene with the biological processes which occur immediately after the injury. Another investigational agent going through drug trials is the female hormone Progesterone which has been shown to reduce the spasms of electrical activity in the brain which accounts for cell death in the wake of an injury.

Click here to read the story from the LA Times about Clazosentan


Tag Lines: traumatic brain injury; Clazosentan; progesterone; reducing TBI severity

About Rolf Gainer Ph.D.

Dr. Rolf Gainer is the founder of the Neurologic Rehabilitation Institute at Brookhaven Hospital in Tulsa, Oklahoma as well as the Neurological Rehabilitation Institute of Ontario, in Toronto, Canada. Dr. Gainer is a psychologist with more than twenty-five years of experience in the treatment and rehabilitation of individuals with brain injuries and a dual diagnosis. Dr. Gainer has designed and operated innovative rehabilitation programs in the United States and Canada for individuals who have been regarded as difficult to serve. He is currently involved in conducting two outcome studies related to the long-term issues faced by individuals with brain injuries and a dual diagnosis. He has presented papers throughout the United States and Canada in many professional conferences and educational forums.
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