Brain Function in Borderline Personality Disorder

The cause of Borderline Personality Disorder has challenged researchers and clinicians for years. The hallmarks of Borderline Personality Disorder: a characteristic negative affective state; high reactivity and diminished ability to self-regulate emotion in previous neuropsychological studies have been attributed to orbitofrontal dysfunction. A study by Silbersweig et al published in the American Journal of Psychiatry 2007 December; 164: 1832  involving 16 individuals with Borderline Personality Disorder  and 14 control subjects showed less activation of the subgenual anterior cingulate cortex and the posterior medial orbitofrontal cortex than the controls did and more activity in the left and right extended amygdala and ventral striatum. This study is important in helping  individuals with Borderline Personality Disorder with more specific pharmacological interventions and in using more targeted approaches to help individuals learn to self-regulate their behavior.

About Rolf Gainer Ph.D.

Dr. Rolf Gainer is the founder of the Neurologic Rehabilitation Institute at Brookhaven Hospital in Tulsa, Oklahoma as well as the Neurological Rehabilitation Institute of Ontario, in Toronto, Canada. Dr. Gainer is a psychologist with more than twenty-five years of experience in the treatment and rehabilitation of individuals with brain injuries and a dual diagnosis. Dr. Gainer has designed and operated innovative rehabilitation programs in the United States and Canada for individuals who have been regarded as difficult to serve. He is currently involved in conducting two outcome studies related to the long-term issues faced by individuals with brain injuries and a dual diagnosis. He has presented papers throughout the United States and Canada in many professional conferences and educational forums.
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